Figure 3

Brain-brain network. (a) application of COMBINER to brain data yields thirty-seven core modules. The tissue- and time-specific expression patterns of each module are presented in the same manner as before. (b) the expression levels and known PPIs of the core module genes are displayed. The shape of a gene represents its inference region, and the color denotes its expression level in that region. Blue lines denote known within-module protein-protein interactions (PPIs), while gray lines denote between-module PPIs. (HB: hemibrain (hemisphere), AY: amygdala, HS: hippocampus, MPFC: medial prefrontal cortex, VS: ventral striatum, SE: septal region and ST: stria terminalis; 5D-1D/10D: 5 day treatment, 1 day/10 day recovery, 10D-1D/ 6 W: 10 day treatment, 1 day/6 week recovery).