Figure 6

TORC1-dependent regulation of Gap1. The schematic diagram is based on literature evidence for the known interactions. Each node in the signaling pathway is annotated with the rank of its information flow score from TORC1 and colored with its functional classification. Yellow nodes represent kinase associated proteins, red nodes are transcription factors, and blue node (Sit4) is a phosphatase. The rest of nodes have a default color of grey. Ranking of nodes based on their information flow scores coincides with our prior knowledge on the structure of this pathway. Top/bottom ranked nodes are discriminated using the computed cutoff value (l) based on differentially expressed genes. The “?” indicates an unknown underlying mechanism, yet to be discovered, that connects TORC1 to the rest of transcription factors.