Table 3 The 16 UniProt identifiers with more than 300 interactions in the integrated PPI network
From: Reconstruction of the experimentally supported human protein interactome: what can we learn?
UniProt Identifier | UniProt Entry Name | Gene Symbol | Protein Name(s) (based on UniProt Naming Convention) | No of PPIs (Degree) |
|---|---|---|---|---|
P0CG48 | UBC_HUMAN | UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 1112 |
P04637 | P53_HUMAN | TP53 | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | 476 |
P63104 | 1433Z_HUMAN | YWHAZ | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | 471 |
P01106 | MYC_HUMAN | MYC | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | 453 |
Q9Y4K3 | TRAF6_HUMAN | TRAF6 | TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) | 424 |
Q13547 | HDAC1_HUMAN | HDAC1 | Histone deacetylase 1 (HD1) (EC 3.5.1.98) | 353 |
P12931 | SRC_HUMAN | SRC | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | 351 |
P62993 | GRB2_HUMAN | GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 341 |
Q14164 | IKKE_HUMAN | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 338 |
P61981 | 1433G_HUMAN | YWHAG | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | 335 |
Q09472 | EP300_HUMAN | EP300 | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) | 331 |
Q9UQL6 | HDAC5_HUMAN | HDAC5 | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | 324 |
P00533 | EGFR_HUMAN | EGFR | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | 313 |
P03372 | ESR1_HUMAN | ESR1 | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | 312 |
P27348 | 1433T_HUMAN | YWHAQ | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | 311 |
Q9Y6K9 | NEMO_HUMAN | IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | 304 |