Figure 1

Similarities and differences of tumour types in gene expression and pathway levels. a) Two first principal components of the gene expression data from all the tumours are plotted. Colours denote the eight different cancer types. Blow-up panel highlights a distinct group of samples from almost all cancer types b) Hierarchical clustering of the pathway aberration profiles indicates that colon and rectal cancers (blue branch) are alike. Gynaecological cancers (red branch) are also similar on pathway level c) Nervous system development is enriched in nearly all GBM, but rarely in any other cancer type. There is a considerable variation in enrichment and depletion frequency in d) Platelet activation pathway e) Drug metabolism through cytochrome p450 and f) Irinotecan pathway.