Figure 2

Clustering of glioblastoma pathway aberration profile. Pathway aberration matrix of GBM shows enriched (in red) and depleted pathways (in green). The bar plot on top of the matrix shows the frequency of enrichment for each pathway, and the bar plot below shows the frequencies of depletion. Some of the most frequently aberrant pathways and processes are annotated to the figure. Hierarchical clustering of the matrix resulted in 12 subgroups (marked in alternating blue and yellow bars, first subgroup being marked with the first blue bar in the bottom), two of which were clinically relevant (subgroup 6 in red and subgroup 12 in green). Some of the subgroups corresponded to the pre-existing molecular classifications in right.