From: Dynamic protein interaction modules in human hepatocellular carcinoma progression
Cluster | GOID | Term | # expec-ted genes | # genes | Adjusted p-value * |
---|---|---|---|---|---|
I | GO:0071842 | cellular component organization at cellular level | 23.3 | 44 | 0.0002 |
I | GO:0007346 | regulation of mitotic cell cycle | 2.6 | 12 | 0.0004 |
I | GO:2000241 | regulation of reproductive process | 1.2 | 8 | 0.0006 |
I | GO:0009968 | negative regulation of signal transduction | 4.3 | 15 | 0.0006 |
I | GO:0043066 | negative regulation of apoptotic process | 4.9 | 16 | 0.0006 |
I | GO:0031577 | spindle checkpoint | 0.4 | 5 | 0.0007 |
I | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 0.4 | 5 | 0.0007 |
I | GO:0000086 | G2/M transition of mitotic cell cycle | 1.3 | 8 | 0.0007 |
I | GO:0048522 | positive regulation of cellular process | 23.2 | 41 | 0.0007 |
I | GO:0006366 | transcription from RNA polymerase II promoter | 10.2 | 24 | 0.0007 |
I | GO:0042221 | response to chemical stimulus | 20.2 | 37 | 0.0008 |
I | GO:0031623 | receptor internalization | 0.4 | 5 | 0.0008 |
I | GO:0048468 | cell development | 10.5 | 24 | 0.0008 |
I | GO:0050658 | RNA transport | 1.0 | 7 | 0.0008 |
I | GO:0016032 | viral reproduction | 3.7 | 13 | 0.0009 |
II | GO:0043065 | positive regulation of apoptotic process | 2.0 | 11 | 0.0003 |
II | GO:0006366 | transcription from RNA polymerase II promoter | 4.3 | 15 | 0.0005 |
III | GO:0016567 | protein ubiquitination | 4.5 | 17 | 0.0001 |
III | GO:0000075 | cell cycle checkpoint | 2.7 | 13 | 0.0001 |
III | GO:0042981 | regulation of apoptotic process | 12.9 | 30 | 0.0001 |
III | GO:0000165 | MAPK cascade | 4.4 | 16 | 0.0001 |
III | GO:0032268 | regulation of cellular protein metabolic process | 12.6 | 29 | 0.0001 |
III | GO:0010627 | regulation of intracellular protein kinase cascade | 5.7 | 18 | 0.0002 |
III | GO:0050863 | regulation of T cell activation | 2.4 | 11 | 0.0002 |
III | GO:0007346 | regulation of mitotic cell cycle | 3.3 | 13 | 0.0002 |
III | GO:0044419 | interspecies interaction between organisms | 4.4 | 15 | 0.0003 |
III | GO:0006511 | ubiquitin-dependent protein catabolic process | 4.0 | 14 | 0.0003 |
III | GO:0045892 | negative regulation of transcription, DNA-dependent | 7.7 | 20 | 0.0005 |
III | GO:0007265 | Ras protein signal transduction | 2.8 | 11 | 0.0006 |
III | GO:0007173 | epidermal growth factor receptor signaling pathway | 1.9 | 9 | 0.0007 |
III | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity | 3.3 | 12 | 0.0007 |
III | GO:0009967 | positive regulation of signal transduction | 6.7 | 18 | 0.0007 |
III | GO:0016310 | phosphorylation | 13.6 | 28 | 0.0008 |
III | GO:0045732 | positive regulation of protein catabolic process | 0.8 | 6 | 0.0008 |
III | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 1.1 | 7 | 0.0008 |
III | GO:0042770 | signal transduction in response to DNA damage | 1.5 | 8 | 0.0009 |
III | GO:0080134 | regulation of response to stress | 6.9 | 18 | 0.0009 |
III | GO:0008285 | negative regulation of cell proliferation | 5.1 | 15 | 0.0009 |
IV* | GO:0044419 * | interspecies interaction between organisms | 2.1 | 11 | 0.0020 |
IV* | GO:0000904 * | cell morphogenesis involved in differentiation | 3.3 | 12 | 0.0099 |
IV* | GO:0007165 * | signal transduction | 18.8 | 33 | 0.0099 |
V | GO:0065008 | regulation of biological quality | 4.1 | 13 | 0.0008 |
V | GO:0001775 | cell activation | 1.4 | 8 | 0.0009 |
V | GO:0018193 | peptidyl-amino acid modification | 1.0 | 7 | 0.0009 |
V | GO:0048011 | nerve growth factor receptor signaling pathway | 0.5 | 5 | 0.0009 |
V | GO:0043066 | negative regulation of apoptotic process | 1.1 | 7 | 0.0009 |
V | GO:0000165 | MAPK cascade | 0.8 | 6 | 0.0009 |
V | GO:0042060 | wound healing | 1.2 | 7 | 0.0009 |
V | GO:0045860 | positive regulation of protein kinase activity | 0.8 | 6 | 0.0009 |
V | GO:0071375 | cellular response to peptide hormone stimulus | 0.5 | 5 | 0.0009 |