Connectivity of miRNA targets. Two shortest path protein-protein interaction networks were built using the Agilent literature search function within Cytoscape 2.8 and topological measures evaluated using CenstiScaPe 2.76. The first network was built using proven targets of miRNAs that are dysregulated during the development of prostate cancer. The other network was built from randomly chosen proteins that are expressed in the prostate but chosen without regard to miRNA status. A whisker plot composed using R displays the differences in the mean node degree between the two PPI networks.