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Table 2 Examples of highly weighted protein domains for each side effect inferred by the L1LOG method

From: Inferring protein domains associated with drug side effects based on drug-target interaction network

Rank Weight Side effect Protein domain ID Protein domain definition
1   anaphylaxis   
  330.0000   PF13558 SbcCD_C (Putative exonuclease SbcCD, C subunit)
  320.0000   PF00060 Lig_chan (Ligand-gated ion channel)
  115.8250   PF08491 SE (Squalene epoxidase)
  113.4802   PF00989 PAS (PAS fold)
  74.9419   PF05790 C2-set (Immunoglobulin C2-set domain)
2   tardive dyskinesia   
  330.0000   PF10320 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)
3   labyrinthitis   
  330.0000   PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
  70.4820   PF10140 YukC (WXG100 protein secretion system (Wss), protein YukC)
4   shortness of breath   
  330.0000   PF02898 NO_synthase (Nitric oxide synthase, oxygenase domain)
  325.3147   PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
  324.4456   PF02931 Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)
  100.7863   PF10320 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)
5   priapism   
  330.0000   PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
  112.9922   PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
  2.0630   PF00206 Lyase_1 (Lyase)
6   nasal congestion   
  330.0000   PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
  330.0000   PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
7   weakness   
  330.0000   PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
8   burning sensation   
  327.1335   PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
  14.2660   PF02867 Ribonuc_red_lgC (Ribonucleotide reductase, barrel domain)
  7.4168   PF03522 KCl_Cotrans_1 (K-Cl Co-transporter type 1 (KCC1))
  5.7520   PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
  0.3741   PF00209 SNF (Sodium:neurotransmitter symporter family)
9   glycosuria   
  326.7361   PF00191 Annexin (Annexin)
  145.3436   PF08377 MAP2_projctn (MAP2/Tau projection domain)
  49.9279   PF03491 5HT_transporter (Serotonin (5-HT) neurotransmitter transporter, N-terminus)
  48.0767   PF02222 ATP-grasp (ATP-grasp domain)
  32.5342   PF00698 Acyl_transf_1 (Acyl transferase domain)
10   hypoventilation   
  292.0382   PF02898 NO_synthase (Nitric oxide synthase, oxygenase domain)
  281.0425   PF02931 Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)