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Table 3 Examples of highly weighted side effects for each protein domain inferred by the L1LOG method

From: Inferring protein domains associated with drug side effects based on drug-target interaction network

Rank Weight Protein domain ID Protein domain definition Side effect
1   PF13558 SbcCD_C (Putative exonuclease SbcCD, C subunit)  
  330.0000    anaphylaxis
  41.1178    allergic reaction
2   PF10320 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)  
  330.0000    tardive dyskinesia
  216.3340    mental depression
  102.3075    regurgitation
  100.7863    shortness of breath
  90.8773    hyperprolactinemia
3   PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)  
  330.0000    labyrinthitis
  330.0000    nasal congestion
  327.1335    burning sensation
  266.0200    torticollis
  225.7442    testicular swelling
4   PF02898 NO_synthase (Nitric oxide synthase, oxygenase domain)  
  330.0000    shortness of breath
  292.0382    hypoventilation
  232.9827    respiratory arrest
  229.9422    increased salivation
  204.4183    blindness
5   PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)  
  330.0000    priapism
  330.0000    nasal congestion
  330.0000    weakness
  325.3147    shortness of breath
  279.9735    ptosis
6   PF00191 Annexin (Annexin)  
  326.7361    glycosuria
  117.1047    vasculitis
  95.9706    sialadenitis
  79.3155    COPD
  71.9669    choking
7   PF02931 Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)  
  324.4456    shortness of breath
  281.0425    hypoventilation
  244.4901    increased salivation
  228.2349    respiratory arrest
  221.8014    drug dependence
8   PF00060 Lig-chan (Ligand-gated ion channel)  
  320.0000    anaphylaxis
  19.4911    allergic reaction
9   PF08377 MAP2_projctn (MAP2/Tau projection domain)  
  251.7744    hyperuricemia
  145.3436    glycosuria
  47.3304    sialadenitis
  44.6506    choking
  36.2648    polydipsia
10   PF14396 CFTR_R (Cystic fibrosis TM conductance regulator (CFTR), regulator domain)  
  239.2866    gallbladder disease
  212.0452    gynecomastia
  156.3952    paronychia
  134.2967    prostatism
  131.3925    cervical erosion