From: Inferring protein domains associated with drug side effects based on drug-target interaction network
Rank | Weight | Protein domain ID | Protein domain definition | Side effect |
---|---|---|---|---|
1 | Â | PF13558 | SbcCD_C (Putative exonuclease SbcCD, C subunit) | Â |
 | 330.0000 |  |  | anaphylaxis |
 | 41.1178 |  |  | allergic reaction |
2 | Â | PF10320 | 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx) | Â |
 | 330.0000 |  |  | tardive dyskinesia |
 | 216.3340 |  |  | mental depression |
 | 102.3075 |  |  | regurgitation |
 | 100.7863 |  |  | shortness of breath |
 | 90.8773 |  |  | hyperprolactinemia |
3 | Â | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) | Â |
 | 330.0000 |  |  | labyrinthitis |
 | 330.0000 |  |  | nasal congestion |
 | 327.1335 |  |  | burning sensation |
 | 266.0200 |  |  | torticollis |
 | 225.7442 |  |  | testicular swelling |
4 | Â | PF02898 | NO_synthase (Nitric oxide synthase, oxygenase domain) | Â |
 | 330.0000 |  |  | shortness of breath |
 | 292.0382 |  |  | hypoventilation |
 | 232.9827 |  |  | respiratory arrest |
 | 229.9422 |  |  | increased salivation |
 | 204.4183 |  |  | blindness |
5 | Â | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) | Â |
 | 330.0000 |  |  | priapism |
 | 330.0000 |  |  | nasal congestion |
 | 330.0000 |  |  | weakness |
 | 325.3147 |  |  | shortness of breath |
 | 279.9735 |  |  | ptosis |
6 | Â | PF00191 | Annexin (Annexin) | Â |
 | 326.7361 |  |  | glycosuria |
 | 117.1047 |  |  | vasculitis |
 | 95.9706 |  |  | sialadenitis |
 | 79.3155 |  |  | COPD |
 | 71.9669 |  |  | choking |
7 | Â | PF02931 | Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain) | Â |
 | 324.4456 |  |  | shortness of breath |
 | 281.0425 |  |  | hypoventilation |
 | 244.4901 |  |  | increased salivation |
 | 228.2349 |  |  | respiratory arrest |
 | 221.8014 |  |  | drug dependence |
8 | Â | PF00060 | Lig-chan (Ligand-gated ion channel) | Â |
 | 320.0000 |  |  | anaphylaxis |
 | 19.4911 |  |  | allergic reaction |
9 | Â | PF08377 | MAP2_projctn (MAP2/Tau projection domain) | Â |
 | 251.7744 |  |  | hyperuricemia |
 | 145.3436 |  |  | glycosuria |
 | 47.3304 |  |  | sialadenitis |
 | 44.6506 |  |  | choking |
 | 36.2648 |  |  | polydipsia |
10 | Â | PF14396 | CFTR_R (Cystic fibrosis TM conductance regulator (CFTR), regulator domain) | Â |
 | 239.2866 |  |  | gallbladder disease |
 | 212.0452 |  |  | gynecomastia |
 | 156.3952 |  |  | paronychia |
 | 134.2967 |  |  | prostatism |
 | 131.3925 |  |  | cervical erosion |