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Table 1 Summary of the pathways considered together with the objectives used for each example

From: Global dynamic optimization approach to predict activation in metabolic pathways

Label Short description Problem formulation
   Single-objective Ref. Multi-objective
LPN3B Linear pathway with three enzymatic reactions Min. final time [7] Min. final time and intermediate consumption
LPDN4 Linear pathway with four enzymatic reactions Min. final time plus enzyme consumption [6] Min. final time and enzyme consumption
GDB Branched pathway with four enzymatic reactions Min. final time [15] a) Min. final time and enzyme consumption
     b) Max. concentration of pathway products
S C Simplified model of the central metabolism of Saccharomyces cerevisiae Max. survival time [3, 4] Max. survival time and min. enzyme cost