Distribution of correlation coefficient before and after filtering. Threshold algorithms filter a network by removing edges whose weights are below an arbitrary cutoff. Such a network would have lost its multiscale structure and thus its core structure. We probe the distribution of the gene expression correlation coefficient to establish whether the multiscale structure of the immunome interactome is retained in the filtered T cell PPI network. The red and blue curves represent, respectively, the distribution of gene expression correlation before and after filtering. The filtering approach preserves a broad distribution of link weights, i.e., most with large weights and some with small weights.