Comparison of T cell PPI network and link weight-randomized networks. Robustness analysis on the filtering procedure was performed by randomizing the immunome interactome link weights to introduce noise. Thirty iterations were conducted so that a fraction of links are selected randomly and their weights randomly reassigned for each iteration. The Link Weight-Randomized Network (LWRN) was filtered and node degree, average path length, betweenness centrality of both the nodes and the links, clustering coefficient of the network, and the intersection between TPPIN and the LWRNs, were calculated. The blue line curves are for the LWRNs and red lines for the TPPIN. A. Change in average degree, B. change in mean path length, C. change in mean betweenness of nodes, D. change in mean betweenness of links, E. change in mean clustering coefficient, F. Link intersection between TPPIN and LWRNs.