T cell PPI Network mapped to TCR, with main JAK-STAT and MAPK signaling pathways. The figure shows the TCR and the main JAK-STAT and MAPK signaling networks that are connected to the TCR-dependent T cell response. The pathway information is adapted from the KEGG Pathways resource. The TPPIN proteins are represented by red-colored boxes with protein names in white text. The signaling network demonstrates the effectiveness of the filtering approach as many of the central proteins in T cell response are left intact after filtering.