A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

Table 4 MetaCore enrichment for disease processes in the OI-MET-TF gene set

Disease phenotype	% of genes annotated for:	p-Value
Pathologic processes	84.0	8.6E-46
Rheumatic diseases	72.0	9.2E-44
Connective tissue diseases	72.0	4.9E-40
Arthritis	70.7	3.2E-41
Joint diseases	70.7	7.1E-41
Arthritis, rheumatoid	69.3	1.8E-42
Inflammation	62.7	1.8E-46
Dry eye syndromes	54.7	3.4E-43
Lacrimal apparatus diseases	54.7	3.4E-43
Sjogren’ s syndrome	53.3	1.4E-43
Xerostomia	53.3	1.4E-43
Salivary gland diseases	53.3	5.4E-40

Disease phenotypes consistent with cancers, as well as inflammation are enriched in annotation for the OI-MET-TF set. (Note that p-values are not adjusted for multiple hypothesis tests).

ISSN: 1752-0509