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Table 6 Enrichment for binding motifs for TF pairs in the OI-MET gene set

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

Motif pair Observed enrichment in OI-MET promoters for motif pair Expected enrichment Difference
V$ AP1F V$ EBOX 1.38 1.07 0.31
V$ IRFF V$ OVOL 0.91 0.81 0.10
V$ AP1R V$ EBOX 1.18 1.09 0.09
V$ AP1F V$ STAT 1.07 1.00 0.07
V$ AP1R V$ STAT 1.07 1.00 0.07
V$ AP1F V$ IRFF 0.99 0.93 0.06
V$ NFKB V$ STAT 1.20 1.14 0.06
V$ AP1F V$ AP1R 1.04 0.99 0.05
V$ AP1F V$ CREB 1.03 0.99 0.04
V$ IRFF V$ STAT 0.95 0.91 0.04
V$ AP1F V$ NFKB 1.19 1.16 0.03
V$ AP1F V$ MYBL 0.96 0.93 0.03
V$ MYBL V$ NFKB 1.12 1.10 0.02
V$ AP1R V$ IRFF 0.97 0.95 0.02
V$ AP1R V$ MYBL 0.97 0.95 0.02
V$ IRFF V$ MYBL 0.89 0.87 0.02
V$ AP1R V$ CREB 1.02 1.01 0.01
V$ MYBL V$ OVOL 0.82 0.82 0.00
V$ AP1R V$ NFKB 1.18 1.19 −0.01
V$ AP1R V$ OVOL 0.92 0.95 −0.03
V$ MYBL V$ STAT 0.89 0.92 −0.03
V$ OVOL V$ STAT 0.82 0.85 −0.03
V$ EBOX V$ STAT 1.05 1.09 −0.04
V$ AP1F V$ OVOL 0.82 0.87 −0.05
V$ CREB V$ NFKB 1.11 1.16 −0.05
V$ CREB V$ IRFF 0.87 0.93 −0.06
V$ CREB V$ STAT 0.91 0.97 −0.06
V$ IRFF V$ NFKB 1.01 1.09 −0.08
V$ EBOX V$ IRFF 0.92 1.00 −0.08
V$ CREB V$ MYBL 0.85 0.93 −0.08
V$ EBOX V$ NFKB 1.17 1.25 −0.08
V$ CREB V$ OVOL 0.77 0.87 −0.10
V$ NFKB V$ OVOL 0.92 1.02 −0.10
V$ EBOX V$ OVOL 0.81 0.93 −0.12
V$ EBOX V$ MYBL 0.86 1.01 −0.15
V$ CREB V$ EBOX 0.91 1.07 −0.16
  1. The AP1/MYC binding motif pair is much more common in the OI-MET promoters than would be expected if they were independent.