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Table 6 Enrichment for binding motifs for TF pairs in the OI-MET gene set

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

Motif pair

Observed enrichment in OI-MET promoters for motif pair

Expected enrichment

Difference

V$ AP1F V$ EBOX

1.38

1.07

0.31

V$ IRFF V$ OVOL

0.91

0.81

0.10

V$ AP1R V$ EBOX

1.18

1.09

0.09

V$ AP1F V$ STAT

1.07

1.00

0.07

V$ AP1R V$ STAT

1.07

1.00

0.07

V$ AP1F V$ IRFF

0.99

0.93

0.06

V$ NFKB V$ STAT

1.20

1.14

0.06

V$ AP1F V$ AP1R

1.04

0.99

0.05

V$ AP1F V$ CREB

1.03

0.99

0.04

V$ IRFF V$ STAT

0.95

0.91

0.04

V$ AP1F V$ NFKB

1.19

1.16

0.03

V$ AP1F V$ MYBL

0.96

0.93

0.03

V$ MYBL V$ NFKB

1.12

1.10

0.02

V$ AP1R V$ IRFF

0.97

0.95

0.02

V$ AP1R V$ MYBL

0.97

0.95

0.02

V$ IRFF V$ MYBL

0.89

0.87

0.02

V$ AP1R V$ CREB

1.02

1.01

0.01

V$ MYBL V$ OVOL

0.82

0.82

0.00

V$ AP1R V$ NFKB

1.18

1.19

−0.01

V$ AP1R V$ OVOL

0.92

0.95

−0.03

V$ MYBL V$ STAT

0.89

0.92

−0.03

V$ OVOL V$ STAT

0.82

0.85

−0.03

V$ EBOX V$ STAT

1.05

1.09

−0.04

V$ AP1F V$ OVOL

0.82

0.87

−0.05

V$ CREB V$ NFKB

1.11

1.16

−0.05

V$ CREB V$ IRFF

0.87

0.93

−0.06

V$ CREB V$ STAT

0.91

0.97

−0.06

V$ IRFF V$ NFKB

1.01

1.09

−0.08

V$ EBOX V$ IRFF

0.92

1.00

−0.08

V$ CREB V$ MYBL

0.85

0.93

−0.08

V$ EBOX V$ NFKB

1.17

1.25

−0.08

V$ CREB V$ OVOL

0.77

0.87

−0.10

V$ NFKB V$ OVOL

0.92

1.02

−0.10

V$ EBOX V$ OVOL

0.81

0.93

−0.12

V$ EBOX V$ MYBL

0.86

1.01

−0.15

V$ CREB V$ EBOX

0.91

1.07

−0.16

  1. The AP1/MYC binding motif pair is much more common in the OI-MET promoters than would be expected if they were independent.