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Table 1 Genes with SMAD-dependent trajectories identified by CADBIOM

From: An integrative modeling framework reveals plasticity of TGF-β signaling

PID ID

HUGO ID

Description

COX_2*

PTGS2

Prostaglandin-endoperoxide synthase 2

DAPK1 *

DAPK1

Death-associated protein kinase 1

GSC

GSC

Goosecoid homeobox

ID1

ID1

Inhibitor of DNA binding 1

IFNB

IFNB1

Interferon, beta 1

IgA1

IGHA1

Immunoglobulin heavy constant alpha 1

IL10

IL10

Interleukin 10

IL5*

IL5

Interleukin 5 (colony-stimulating factor, eosinophil)

JUN*

JUN

Jun oncogene

KLK2

KLK2

Kallikrein-related peptidase 2

Laminin gamma1

LAMC1

Laminin, gamma 1

MEF2C

MEF2C

Myocyte enhancer factor 2C

NOS2*

NOS2

Nitric oxide synthase 2, inducible

p15INK4b

CDKN2B

Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

p21CIP1

CDKN1A

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

RAB7

RAB7A

RAB7A, member RAS oncogene family

SMAD7

SMAD7

SMAD family member 7

SNAI1

SNAI1

Snail homolog 1 (Drosophila)

SOCS3

SOCS3

Suppressor of cytokine signaling 3

TCF3

TCF3

Transcription factor 3

TLX2

TLX2

T-cell leukemia homeobox 2

TRPC6

TRPC6

Transient receptor potential cation channel, subfamily C, member 6

TRPV1

TRPV1

Transient receptor potential cation channel, subfamily V, member 1

  1. The Table lists genes with SMAD-dependent trajectories. Gene names (ID) are given according to their nomenclature in the PID and HUGO databases, respectively, and are followed by their description. Asterisks denote genes that are also found with non-SMAD-dependent trajectories (see Text and Additional file 4: Table S3).