Figure 4
Analysis of global changes in gene expression is consistent with TOM. The 5910 differentially expressed genes targeted by upregulated miRNAs were divided into 6 groups based on the number of miRNAs targeting each gene (The number of genes included in each group are presented on top of the bars). (A) An inverse relationship exists between the number of upregulated miRNAs targeting genes and the percentage of these genes displaying the unexpected PC change in expression. The chi-square test for trend is X 2 = 311.5, p < < 0.0001, indicating a significant increase in downregulated targets as the number of targeting microRNAs increases. B) The strength of miRNA regulatory control is diminished as the number of deregulated repressor genes increase. A chi-square test for trend for the miRNAs in this figure (4B) is X 2 = 444.6, p < < 0.0001, indicating a significant increase in downregulated miRNA targets as the number of miRNAs increases. The chi-square test for trend for the transcriptional repressors in this figure (4B) is X 2 = 1904.6, p < < 0.0001, indicating a significant increase in upregulated targets as the number of repressors increases.