Table 2 Change in model parameters for Models 2 after optimization
From: Analysis of Wnt signaling β-catenin spatial dynamics in HEK293T cells
Parameters | Initial conditions | Optimized with active transport | Fold change | Optimized without active transport | Fold change | ||
|---|---|---|---|---|---|---|---|
- | Steady state | CHX | WNT | - | CHX | WNT | - |
B synthesis | 1.306 | 0 | 1.306 | - | 0 | 1.306 | - |
K degradation | 0. 0163 | 0.0163 | 0 | - | 0.0163 | 0 | - |
kR_ cyto | 0.0026 | 0.000647 | 0.25 | 0.00109 | 0.42 | ||
kF_ cyto | 0.00001 | 0.00001 | - | 0.00001 | - | ||
kR_ nuclear | 0.003 | 0.00349 | 1.16 | 0.00743 | 2.48 | ||
kF_ nuclear | 0.0001 | 0.0001 | - | 0.0001 | - | ||
k diffusion | 36 | 39.13 | 1.09 | 1354.1 | 37.6 | ||
| 4.5 | 4.5 | 1 | 0 | - | ||
| 2 | 17.16 | 8.58 | 0 | - | ||