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Figure 5 | BMC Systems Biology

Figure 5

From: Stabilization of perturbed Boolean network attractors through compensatory interactions

Figure 5

The modified reduced ABA signaling network. The 7 node reduced network of [44], adapted from the full model of [31]. Black arrows represent activation, and red dashed arrows represent inhibition. The bold red arrow from KOUT to Ca2+ c is a possible addition to the network that preserves the limit cycle of the unmodified and undamaged network in response to the constitutive loss of CaIM. The update rules and limit cycle for this network are provided in Tables 3 and 4, respectively. The full names corresponding to the abbreviated node labels are (see [31]): CIS, Ca2+ c influx to the cytosol from intracellular stores; Ca2+ c, cytosolic Ca2+ increase; Ca2+ ATPase, Ca2+ ATPases and Ca2+/H+ antiporters responsible for Ca2+ efflux from the cytosol; CaIM, Ca2+ influx across the plasma membrane; Depolar, plasma membrane depolarization; KOUT, K+ efflux through slowly activating outwardly-rectifying K+ channels at the plasma membrane.

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