Figure 3

Graphical representation of the model structure in SBGN for the Lysosome-CMA compartment. Upper part of the figure: The monomer and dimer WT ASYN species (WTasyn & WTasyn2) bind to the Lamp2a receptor (blue colored reactions) and are then inserted to the lysosome in order to be degraded. Oligomers of WT ASYN (WTasyn3-WTasyn9) can also bind to Lamp2a (blue colored reactions) and although are not inserted into the lysosome, this binding is reversible (red colored reactions). Finally, the WT ASYN can also oligomerize on top of Lamp2a (black colored reactions). Lower part of the figure: DA-modified ASYN monomeric species (DopModWTasyn) bind to Lamp2a receptor (blue colored reaction) in an irreversible manner. Moreover, the modified species can also form oligomers on top of Lamp2a (black colored reactions), further suppressing this repressor.