Table 1 Metabolic pathways with significant dysregulation in lung cancer

Glycolysis/Gluconeogenesis

< 1E-16

20

9

4

Citrate cycle (TCA cycle)

< 1E-16

12

9

2

Fructose and mannose metabolism

< 1E-16

10

8

1

Fatty acid metabolism

< 1E-16

15

11

8

Steroid biosynthesis

< 1E-16

7

11

11

Ubiquinone and other terpenoid-quinone biosynthesis

< 1E-16

8

0

3

Purine metabolism

< 1E-16

63

22

6

Pyrimidine metabolism

< 1E-16

55

16

5

Alanine, aspartate and glutamate metabolism

< 1E-16

16

9

2

Cysteine and methionine metabolism

< 1E-16

11

12

2

Arginine and proline metabolism

< 1E-16

16

26

6

Tyrosine metabolism

< 1E-16

5

20

19

Tryptophan metabolism

< 1E-16

9

18

10

N-Glycan biosynthesis

< 1E-16

19

9

5

Amino sugar and nucleotide sugar metabolism

< 1E-16

15

20

2

Inositol phosphate metabolism

< 1E-16

5

14

11

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

< 1E-16

8

5

2

Glycerophospholipid metabolism

< 1E-16

13

17

11

Arachidonic acid metabolism

< 1E-16

13

8

15

Sphingolipid metabolism

< 1E-16

7

17

3

Glycosphingolipid biosynthesis - lacto and neolacto series

< 1E-16

31

13

3

Glycosphingolipid biosynthesis - ganglio series

< 1E-16

4

8

11

Pyruvate metabolism

< 1E-16

9

14

4

One carbon pool by folate

< 1E-16

16

8

2

Vitamin B6 metabolism

< 1E-16

7

0

4

Nicotinate and nicotinamide metabolism

< 1E-16

5

8

5

Folate biosynthesis

< 1E-16

9

8

3

Porphyrin and chlorophyll metabolism

< 1E-16

9

7

1

Drug metabolism - cytochrome P450

< 1E-16

8

15

23

Drug metabolism - other enzymes

< 1E-16

15

7

6

Metabolic pathways

< 1E-16

418

388

201

Primary bile acid biosynthesis

8.77E-15

12

18

16

Butanoate metabolism

1.75E-14

8

4

2

Valine, leucine and isoleucine degradation

2.63E-14

11

24

2

Glutathione metabolism

6.14E-14

13

9

0

Starch and sucrose metabolism

2.10E-13

7

14

6

Steroid hormone biosynthesis

3.86E-13

32

45

21

Glycine, serine and threonine metabolism

2.05E-12

12

15

2

Lysine degradation

7.22E-12

10

6

0

Fatty acid elongation in mitochondria

9.09E-11

12

6

7