Skip to main content

Advertisement

Table 1 Metabolic pathways with significant dysregulation in lung cancer

From: Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling

Pathway P* Up* No_ch* Down*
Glycolysis/Gluconeogenesis < 1E-16 20 9 4
Citrate cycle (TCA cycle) < 1E-16 12 9 2
Fructose and mannose metabolism < 1E-16 10 8 1
Fatty acid metabolism < 1E-16 15 11 8
Steroid biosynthesis < 1E-16 7 11 11
Ubiquinone and other terpenoid-quinone biosynthesis < 1E-16 8 0 3
Purine metabolism < 1E-16 63 22 6
Pyrimidine metabolism < 1E-16 55 16 5
Alanine, aspartate and glutamate metabolism < 1E-16 16 9 2
Cysteine and methionine metabolism < 1E-16 11 12 2
Arginine and proline metabolism < 1E-16 16 26 6
Tyrosine metabolism < 1E-16 5 20 19
Tryptophan metabolism < 1E-16 9 18 10
N-Glycan biosynthesis < 1E-16 19 9 5
Amino sugar and nucleotide sugar metabolism < 1E-16 15 20 2
Inositol phosphate metabolism < 1E-16 5 14 11
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis < 1E-16 8 5 2
Glycerophospholipid metabolism < 1E-16 13 17 11
Arachidonic acid metabolism < 1E-16 13 8 15
Sphingolipid metabolism < 1E-16 7 17 3
Glycosphingolipid biosynthesis - lacto and neolacto series < 1E-16 31 13 3
Glycosphingolipid biosynthesis - ganglio series < 1E-16 4 8 11
Pyruvate metabolism < 1E-16 9 14 4
One carbon pool by folate < 1E-16 16 8 2
Vitamin B6 metabolism < 1E-16 7 0 4
Nicotinate and nicotinamide metabolism < 1E-16 5 8 5
Folate biosynthesis < 1E-16 9 8 3
Porphyrin and chlorophyll metabolism < 1E-16 9 7 1
Drug metabolism - cytochrome P450 < 1E-16 8 15 23
Drug metabolism - other enzymes < 1E-16 15 7 6
Metabolic pathways < 1E-16 418 388 201
Primary bile acid biosynthesis 8.77E-15 12 18 16
Butanoate metabolism 1.75E-14 8 4 2
Valine, leucine and isoleucine degradation 2.63E-14 11 24 2
Glutathione metabolism 6.14E-14 13 9 0
Starch and sucrose metabolism 2.10E-13 7 14 6
Steroid hormone biosynthesis 3.86E-13 32 45 21
Glycine, serine and threonine metabolism 2.05E-12 12 15 2
Lysine degradation 7.22E-12 10 6 0
Fatty acid elongation in mitochondria 9.09E-11 12 6 7
  1. *Up is the number of up-regulated reactions in lung adenocarcinoma when compared to normal controls, down the number of down-regulated reactions; and no_ch the number of reactions without notable changes. P is the Bonferroni corrected P-value for the pathway pattern.