Table 5 Description and ranges for the Land-model parameters used for parameter identifiability analysis
Parameter | Description | Minimum value | Maximum value | Default value |
|---|---|---|---|---|
T ref | Reference tension (kPa) | 100 | 140 | 120 |
Ca 50ref | Calcium sensitivity at resting sarcomere length (μM) | 0.5 | 0.8 | 0.7 |
TRPN 50 | Troponin C sensitivity | 0.25 | 0.5 | 0.35 |
n TRPN | Hill coefficient for cooperative binding of Ca to TnC | 1 | 2.5 | 2 |
k TRPN | Unbinding rate of Ca from TnC (ms-1) | 0 | 0.5 | 0.1 |
n xb | Hill coefficient for cooperative crossbridge action | 3 | 7 | 5 |
k xb | Scaling factor for the rate of crossbridge binding (ms-1) | 0 | 0.6 | 0.1 |
β 1 | Magnitude of length-dependent activation effects | -2 | -1 | -1.5 |
β 0 | Magnitude of filament overlap effects | 1 | 5 | 1.65 |