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Table 5 Description and ranges for the Land-model parameters used for parameter identifiability analysis

From: Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Parameter Description Minimum value Maximum value Default value
T ref Reference tension (kPa) 100 140 120
Ca 50ref Calcium sensitivity at resting sarcomere length (μM) 0.5 0.8 0.7
TRPN 50 Troponin C sensitivity 0.25 0.5 0.35
n TRPN Hill coefficient for cooperative binding of Ca to TnC 1 2.5 2
k TRPN Unbinding rate of Ca from TnC (ms-1) 0 0.5 0.1
n xb Hill coefficient for cooperative crossbridge action 3 7 5
k xb Scaling factor for the rate of crossbridge binding (ms-1) 0 0.6 0.1
β 1 Magnitude of length-dependent activation effects -2 -1 -1.5
β 0 Magnitude of filament overlap effects 1 5 1.65