Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Table 7 Niederer-model parameter values corresponding to the model output values closest to the target ( α _r2 = 0)

Parameter	Parameter set 1	Parameter set 2	Parameter set 3	Parameter set 4	Mean value	Standard deviation
Ca _50ref	3.51e-04	3.45e-04	3.45e-04	3.71e-04	3.53e-04	1.23e-05
k _refoff	0.11	0.12	0.08	0.14	0.11	0.03
k _on	231.4	268.2	240.2	294.0	258.4	28.4
β ₀	0.66	0.28	0.92	0.71	0.64	0.26
β ₁	-1.33	-1.34	-1.24	-1.47	-1.35	0.10
γ	3.73	4.56	4.61	4.29	4.30	0.41
nH	11.31	12.50	14.22	11.70	12.43	1.29
T _ref	128.3	126.2	113.4	104.1	118.0	11.3
α ₀	0.03	0.02	0.04	0.05	0.04	0.01
α _r1	0.31	0.28	0.38	0.35	0.33	0.05

Model outputs were matched to target data for 90, 100 and 110% of resting sarcomere length.

ISSN: 1752-0509