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Table 7 Niederer-model parameter values corresponding to the model output values closest to the target ( α r2 = 0)

From: Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Parameter Parameter set 1 Parameter set 2 Parameter set 3 Parameter set 4 Mean value Standard deviation
Ca 50ref 3.51e-04 3.45e-04 3.45e-04 3.71e-04 3.53e-04 1.23e-05
k refoff 0.11 0.12 0.08 0.14 0.11 0.03
k on 231.4 268.2 240.2 294.0 258.4 28.4
β 0 0.66 0.28 0.92 0.71 0.64 0.26
β 1 -1.33 -1.34 -1.24 -1.47 -1.35 0.10
γ 3.73 4.56 4.61 4.29 4.30 0.41
nH 11.31 12.50 14.22 11.70 12.43 1.29
T ref 128.3 126.2 113.4 104.1 118.0 11.3
α 0 0.03 0.02 0.04 0.05 0.04 0.01
α r1 0.31 0.28 0.38 0.35 0.33 0.05
  1. Model outputs were matched to target data for 90, 100 and 110% of resting sarcomere length.