Table 9 Summary of functional specialization in the central zones of HFPIN
From: Protein interaction networks as metric spaces: a novel perspective on distribution of hubs
Percentage of proteins | ||||
|---|---|---|---|---|
Enriched pathway | Zone 1 | Zone 2 | Zone 3 | Zone 4 |
Signal transduction | 38% | 24.8% | - | - |
Immune system | 29.8% | 10.6% | 4.5% | - |
Hemostasis | 17% | 5.7% | 2.7% | - |
Disease | 16.8% | 8% | 4.1% | - |
Gene expression | 8.2% | 8.8% | 9.8% | - |
Metabolism | 5.1% | 8.4% | 7.6% | 10.4% |
Membrane trafficking | - | - | 1.2% | 2.8% |
Neuronal system | 4.8% | 2.5% | 2.3% | 3.3% |
Transmembrane transport of small molecules | - | 1.9% | 2.4% | 3.6% |