Figure 10

Topology of the HOG signaling pathway in yeast. This pathway topology was proposed as the best approximating model topology in [26]. We used this model as our true model ODE _T for data generation in our simulations on HOG signaling pathway. The black lines with small arrow tips depict the transition between different species in the model like production, degradation or complex formation. The black lines with circle tips depict the phosphorylation process by kinases. The lines with open triangle tips show activating regulatory interactions where as lines with blunt ends show deactivating regulatory interactions. The red colored double arrow denotes the post translational regulation of glycerol production by the active phosphorylated Hog1 protein. We removed this regulatory interaction in our simplified model ODE _S .