Figure 4
From: Source and regulation of flux variability in Escherichia coli
Components of flux variability vs. ammonia uptake. Black circle represents Δ int , red circle represents Δ int + Δ ext and green circle represents Δ tot = Δ int + Δ ext + Δ gro . (A) Aerobic conditions without coordination of carbon and nitrogen uptake. (B) Anaerobic conditions without coordination of carbon and nitrogen uptake. (C) Aerobic conditions with coordination of carbon and nitrogen uptake. (D) Anaerobic conditions with coordination of carbon and nitrogen uptake. The contribution of Δ int and Δ ext to flux variability, at low ammonia uptakes, disappears when the coordination of carbon and nitrogen utilization is imposed. Under coordination of carbon and nitrogen utilization, Δ gro is the only significant component of flux variability.