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Table 11 Distribution of essential, drug target and classical cancer proteins in CN zones

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Zone Essential Disease Drug Oncogenes Tumour
  genes associated targets   suppressors
1 206 (38%) 234 (43.2%) 97 (17.8%) 17 (3.1%) 20 (3.6%)
2 1084 (18%) 1279 (21.3%) 365 (6%) 32 (0.5%) 42 (0.6%)
3 315 (9.3%) 415 (12.4%) 59 (1.7%) 2 (0.05%) 4 (0.1%)
4 28 (7.6%) 56 (15.3%) 3 (0.8%) 1 (0.2%) 1 (0.2%)
5 2 (3.2%) 9 (14.8%) 1 (1.6%) - -