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Table 2 Functional specialization of HFPIN zones defined by distance from the network centre

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Enriched Pathway

Zone 1

Zone 2

Zone 3

Zone 4

Zone 5

Signal transduction

38.1%

26.4%

-

-

-

Immune system

31.3%

8%

5.1%

-

-

Hemostasis

18.4%

5.9%

2.5%

-

-

Disease

17.5%

9.1%

4.4%

-

-

Gene Expression

7.9%

8.8%

11.9%

-

-

Metabolism

10.7%

9.1%

8.7%

11.3%

16.3%

Transmembrane transport of small molecules

-

2%

2.5%

3.9%

13.4%

Metabolic pathways

2.4%

4.8%

6.7%

12.7%

25%

  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.