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Table 2 Functional specialization of HFPIN zones defined by distance from the network centre

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Enriched Pathway Zone 1 Zone 2 Zone 3 Zone 4 Zone 5
Signal transduction 38.1% 26.4% - - -
Immune system 31.3% 8% 5.1% - -
Hemostasis 18.4% 5.9% 2.5% - -
Disease 17.5% 9.1% 4.4% - -
Gene Expression 7.9% 8.8% 11.9% - -
Metabolism 10.7% 9.1% 8.7% 11.3% 16.3%
Transmembrane transport of small molecules - 2% 2.5% 3.9% 13.4%
Metabolic pathways 2.4% 4.8% 6.7% 12.7% 25%
  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.