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Table 4 Summary of cellular function in the central zones of HFPIN

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Cellular

# of proteins

Zone 1

Zone 2

Zone 3

function

    

Signalling pathway

3186

285 (76.2%)

2141 (46.4%)

760 (20.8%)

Positive signals

544

75 (20%)

386 (8.3%)

83 (2.2%)

Negative signals

449

57 (15.2%)

321 (6.9%)

71 (1.9%)

MAPK signalling cascade

394

93 (24.8%)

258 (5.5%)

43 (1.1%)

Apoptosis signalling pathway

38

13 (3.4%)

19 (0.4%)

6 (0.1%)

Positive regulation of apoptosis signalling

22

6 (1.6%)

13 (0.2%)

3 (0.1%)

Negative regulation of apoptosis signalling

10

4 (1%)

3 (0.06%)

3 (0.08%)

  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.