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Table 4 Summary of cellular function in the central zones of HFPIN

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Cellular # of proteins Zone 1 Zone 2 Zone 3
function     
Signalling pathway 3186 285 (76.2%) 2141 (46.4%) 760 (20.8%)
Positive signals 544 75 (20%) 386 (8.3%) 83 (2.2%)
Negative signals 449 57 (15.2%) 321 (6.9%) 71 (1.9%)
MAPK signalling cascade 394 93 (24.8%) 258 (5.5%) 43 (1.1%)
Apoptosis signalling pathway 38 13 (3.4%) 19 (0.4%) 6 (0.1%)
Positive regulation of apoptosis signalling 22 6 (1.6%) 13 (0.2%) 3 (0.1%)
Negative regulation of apoptosis signalling 10 4 (1%) 3 (0.06%) 3 (0.08%)
  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.