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Table 5 Distribution of essential, disease, drug target and classical cancer proteins in HFPIN zones

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Zone

Essential

Disease

Drug

Oncogenes

Tumour

 

roles

associated

targets

 

suppressors

1

161 (43%)

159 (42.5%)

59 (15.7%)

15 (4%)

14 (3.7%)

2

1002 (21.7%)

1184 (25.6%)

346 (7.5%)

32 (0.7%)

42 (0.9%)

3

392 (10.7%)

545 (14.9%)

77 (2.1%)

1 (0.02%)

4 (0.1%)

4

55 (9.3%)

85 (14.4%)

11 (1.8%)

1 (0.2%)

2 (0.3%)

5

10 (9.6%)

19 (18.2%)

3 (2.8%)

-

-

6

-

2 (14.2%)

1 (7.1%)

-

-