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Table 5 Distribution of essential, disease, drug target and classical cancer proteins in HFPIN zones

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Zone Essential Disease Drug Oncogenes Tumour
  roles associated targets   suppressors
1 161 (43%) 159 (42.5%) 59 (15.7%) 15 (4%) 14 (3.7%)
2 1002 (21.7%) 1184 (25.6%) 346 (7.5%) 32 (0.7%) 42 (0.9%)
3 392 (10.7%) 545 (14.9%) 77 (2.1%) 1 (0.02%) 4 (0.1%)
4 55 (9.3%) 85 (14.4%) 11 (1.8%) 1 (0.2%) 2 (0.3%)
5 10 (9.6%) 19 (18.2%) 3 (2.8%) - -
6 - 2 (14.2%) 1 (7.1%) - -