Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Table 9 Functional specialization of CN zones defined by distance from the network centre

Enriched Pathway	Zone 1	Zone 2	Zone 3	Zone 4
Signal transduction	43%	21.6%	-	-
Immune system	32%	10.9%	5.4%	-
MAPK signalling	25.8%	2.3%	-	-
Pathway in cancer	20.7%	3.5%	-	-
Disease	22.6%	9.3%	5.4%	-
Hemostasis	15.9%	5.3%	-	-
Cell Cycle	5.4%	5.5%	3.1%	-
Gene expression	7.8%	8.3%	12.5%	-
Metabolism	13.1%	9.3%	8.8%	15.9%

Percentages indicate proportion of proteins in a zone belonging to the specific functional class.

ISSN: 1752-0509