Skip to main content

Table 9 Functional specialization of CN zones defined by distance from the network centre

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Enriched Pathway Zone 1 Zone 2 Zone 3 Zone 4
Signal transduction 43% 21.6% - -
Immune system 32% 10.9% 5.4% -
MAPK signalling 25.8% 2.3% - -
Pathway in cancer 20.7% 3.5% - -
Disease 22.6% 9.3% 5.4% -
Hemostasis 15.9% 5.3% - -
Cell Cycle 5.4% 5.5% 3.1% -
Gene expression 7.8% 8.3% 12.5% -
Metabolism 13.1% 9.3% 8.8% 15.9%
  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.