Figure 4

Network training methodology for fluconazole treatment experiments. S. cerevisiae expression data from 5 microarray experiments were individually added to the original training compendium from Cosgrove et al. Separate SSEM-Lasso runs were performed on each of the modified training compendiums resulting in unique changes to the gene interaction network. Subsequent changes to gene ranks were reported, along with percentile values to evaluate how much “better” or “worse” a gene ranked with a given, modified training compendium.