Skip to main content
Figure 1 | BMC Systems Biology

Figure 1

From: Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression

Figure 1

Primary screen results of the top ten most selective kinase inhibitors. Drugs are ranked based on the IMR-90 to A549 viability ratio. The 3 digit codes identify the compounds: A15: PDK1/Akt1/Flt3 Dual Pathway Inhibitor (CAS 331253-86-2); E20: Cdk/Crk Inhibitor (CAS 784211-09-2); O20: SU9516 (CAS 666837-93-0); H15: MEK1/2 Inhibitor II (CAS 212631-61-3); L13: PI 3-Kα Inhibitor VIII (CAS 372196-77-5); G10: Fascaplysin, Synthetic (CAS 114719-57-2); D07: Cdk2 Inhibitor II (CAS 222035-13-4); C16: Cdk1/2 Inhibitor III (CAS 443798-55-8); M16: GSK3b Inhibitor XII, TWS119 (CAS 601514-19-6); N05: Reversine (CAS 656820-32-5). The chemical structure of these compounds is given in a Additional file 2.

Back to article page

BMC Systems Biology

ISSN: 1752-0509

Contact us