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Figure 3 | BMC Systems Biology

Figure 3

From: Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression

Figure 3

Secondary screen results of the top ten most selective drugs (1000 nM) when paired with PDK1/Akt1/Flt3 dual pathway inhibitor at 125 nM. Selectivity is the IMR-90 to A549 viability ratio, as defined in Section 2.1. The 3 digit codes identify the compounds: A12: Alsterpaullone, 2-Cyanoethyl (CAS 852529-97-0); D17: Cdk2/9 Inhibitor (CAS 507487-89-0); K08: K-252a, Nocardiopsis sp. (CAS 97161-97-2); O21: Staurosporine, Streptomyces sp. (CAS 62996-74-1); P15: WHI-P180, Hydrochloride (CAS 211555-08-7); E13: Gö 6976 (CAS 136194-77-9); C09: Compound 56 (CAS 171745-13-4); A10: Alsterpaullone (CAS 237430-03-4); O03: AG 1478, Selective inhibitor of epidermal growth factor receptor (EGFR) protein (CAS 175178-82-2); N05: Reversine (CAS 656820-32-5). The chemical structure of these compounds is given in a Additional file 2.

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BMC Systems Biology

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