|
Kinase
|
Selectivity corr
|
FDR
|
Kinase
|
Selectivity corr
|
FDR
|
|---|
|
Primary screening
|
Secondary screening
|
|---|
|
PRKCZ
|
0.451
|
2.28E-08
|
TGFBR2
|
-0.501
|
8.29E-08
|
|
DMPK
|
0.435
|
7.75E-08
|
CDK4
|
-0.412
|
6.40E-05
|
|
STK39
|
0.430
|
1.15E-07
|
CDC42BPB
|
-0.409
|
6.40E-05
|
|
EPHA8
|
0.420
|
2.33E-07
|
RIPK2
|
-0.399
|
7.73E-05
|
|
ADRBK2
|
0.399
|
1.01E-06
|
DSTYK
|
-0.369
|
0.000413
|
|
PRKACG
|
0.396
|
1.27E-06
|
ACVRL1
|
-0.368
|
0.000413
|
|
CAMK4
|
0.394
|
1.45E-06
|
PAK1
|
-0.367
|
0.000413
|
|
MAP2K2
|
0.393
|
1.53E-06
|
MAPKAPK2
|
-0.364
|
0.000413
|
|
ADRBK1
|
0.392
|
1.62E-06
|
PAK7
|
-0.359
|
0.000424
|
|
PNCK
|
0.382
|
3.29E-06
|
CDK1
|
-0.357
|
0.000429
|
- A negative correlation indicates that inhibition of that particular kinases is associated to a higher selectivity. The top two hits with negative correlation, TGFBR2 and CDK4 are known to have an important role in cell proliferation, invasion and metastasis in lung adenocarcinoma [21, 22].
