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Table 1 Correlations between selectivity and kinase activity from primary and secondary screening

From: Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression

Kinase Selectivity corr FDR Kinase Selectivity corr FDR
Primary screening Secondary screening
PRKCZ 0.451 2.28E-08 TGFBR2 -0.501 8.29E-08
DMPK 0.435 7.75E-08 CDK4 -0.412 6.40E-05
STK39 0.430 1.15E-07 CDC42BPB -0.409 6.40E-05
EPHA8 0.420 2.33E-07 RIPK2 -0.399 7.73E-05
ADRBK2 0.399 1.01E-06 DSTYK -0.369 0.000413
PRKACG 0.396 1.27E-06 ACVRL1 -0.368 0.000413
CAMK4 0.394 1.45E-06 PAK1 -0.367 0.000413
MAP2K2 0.393 1.53E-06 MAPKAPK2 -0.364 0.000413
ADRBK1 0.392 1.62E-06 PAK7 -0.359 0.000424
PNCK 0.382 3.29E-06 CDK1 -0.357 0.000429
  1. A negative correlation indicates that inhibition of that particular kinases is associated to a higher selectivity. The top two hits with negative correlation, TGFBR2 and CDK4 are known to have an important role in cell proliferation, invasion and metastasis in lung adenocarcinoma [21, 22].