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Figure 2 | BMC Systems Biology

Figure 2

From: Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines

Figure 2

Scheme of ErbB dimers related MAPK and PI3K pathway activation. The figure depicts the different homo- and heterodimers of ErbB receptors, induced upon activation via the ligands EGF or HRG. The active dimers then initialise the MAPK and PI3K signalling cascades. The orange (PI3K) and green (MAPK) arrows denote, which dimer activates which pathway.

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BMC Systems Biology

ISSN: 1752-0509

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