Figure 5
Model fit to the omics data at high CsA exposure. Transcriptomics (Nrf2 mRNA, GS mRNA, GCLC mRNA, GCLM mRNA, GST mRNA, GPx mRNA and ABCC2 mRNA) proteomics (GCLM, GS, and MRP2), and metabolomics (γ-GC, and GSH) fold-changes time-course in RPTEC cells during 14 days with repeated 15 μM CsA. The blue line indicates the best fitting (maximum posterior probability) model prediction. The black lines are predictions made with 49 parameter sets randomly drawn from their joint posterior distribution. The red circles represent data.