Figure 7

The PVT1 sub-network. A) Percentage of the miRNAs sponged by PVT1 in the normal-MMI-network. B) Schematic diagram of selected nearest-neighbors of PVT1 in the normal-MMI-network, that are important regulators of breast tissue morphogenesis and development. C) Sketch of the PVT1 locus as it appears in the UCSC genome browser (http://genome.ucsc.edu/), illustrating the PVT1 alternative isoforms (Iso). Boxes represent exons while black lines represent introns. Colored boxes correspond to exons where the seed-complementary sites - for mir-200a/mir-141 (red), and for mir-200b/mir-200c (purple) - occur. Note that two isoforms (Iso 11 and 12) lack seed matches for the mir-200 family.