Figure 5

Expression profiles of driving genes and pathways. A) PPs for Cell Cycle and DNA replication pathways and expression profiles of CLB6, CDC45, MCD1 and RAD53 (Cell Cycle driving genes), POL30 and RFA1 (DNA Replication driving genes). All the genes are overexpressed in the G1 and the S phases simultaneously with DNA replication, and their activation patterns are consistent with their pathway temporal profiles. B) Gene expression for driving genes of the Ubiquitin-mediated Proteolysis (SAF1) and Purine Metabolism (AAH1, CDC34, SKP1) pathways. The SAF1 gene shows an inverse correlation to the expression of the AAH1, CDC34 and SKP1 genes.