Group-IA (n = 25) | Group-IB, (n = 23) | p- values | Group-IIA (n = 21) | Group-IIB , (n = 32) | p- values | Group -IIIA (n = 15) | Group-IIIB (n = 28) | p-values | Group-IVA (n = 20) | Group-IVB (n = 26) | p- values | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | 65.4 | 65.4 | - | 63.9 | 65.4 | - | 58.73 | 68.7 | *** | 63 | 65.96 | - |
Lung Function | - | - | - | - | ||||||||
FEV1 | 1.72 | 0.89 | *** | 1.7 | 0.9 | *** | 1.72 | 0.93 | ** | 1.79 | 0.9 | *** |
FEV1/FVC (%) | 57.88 | 32.43 | *** | 55.0 | 32.5 | *** | 56.53 | 33.93 | *** | 57.1 | 33.04 | *** |
FEV1 reversibility (%) | 7.64 | 4.73 | *** | 11.5 | 7.2 | *** | 11.62 | 5.93 | *** | 10.4 | 5.5 | *** |
Radiologist Emphysema | - | - | - | - | ||||||||
Emphysema severity | 1.2 | 4.2 | *** | 1.3 | 4.2 | *** | 1.336 | 3.7 | *** | 1.275 | 4.2 | *** |
Densitometric Emphysema | - | - | - | - | ||||||||
Emphysema at -950 HU | 6.98 | 33.42 | *** | 6.6 | 31.7 | *** | 7.71 | 28.09 | *** | 7.06 | 33.42 | *** |
Airflow Obstruction | - | - | - | - | ||||||||
GOLD Stage | 2 | 3.3 | *** | 2.0 | 3.3 | *** | 2 | 3.2 | *** | 2 | 3.3 | *** |
Body Mass Index | 30.76 | 21.21 | *** | 27.3 | 24.2 | * | 29.87 | 25.8 | - | 28.67 | 24.42 | * |
Chronic Bronchitis (ATS_CB) 1 = no-CB Phelgm | 1 = 24% | 1 = 30.4% | - | 1 = 85.7% | 1 = 62.5% | - | 1 = 6.7% | 1 = 37% | - | 1-100% | 1 = 46.2% | *** |
1 = no chronic phlegm | 1 = 56% | 1 = 35% | - | 1 = 62% | 1 = 41% | - | 1 = 66.6% | 1 = 33% | - | 1-100% | 1 = 0% | *** |
6 Minute Walk Distance | 428.32 | 330.02 | ** | 508.8 | 273.9 | *** | 438.97 | 321.83 | ** | 462.59 | 322.9 | ** |
Exacerbations 0 = no-Exacerbations | 0 = 68% | 0 = 34.8% | - | 0 = 71.4% | 0 = 28.1% | ** | 0 = 60% | 0 = 37% | - | 0 = 70% | 0 = 38.5% | * |
CCL6 | 7.3 | 6.33 | - | 7.0 | 6.8 | - | 6.19 | 6.73 | - | 8.64 | 6.9 | - |
IL6 | 5.65 | 20.2 | - | 4.3 | 18.6 | - | 2.79 | 6.89 | ** | 3.72 | 18.53 | - |
IL8 | 8.88 | 10.77 | - | 8.3 | 9.4 | - | 7.5 | 10.28 | * | 9.8 | 10.65 | - |
TNFa | 26.99 | 160.32 | - | 31.7 | 162.9 | - | 2.35 | 60.44 | - | 24.14 | 142.3 | - |
CCL18 | 130.3 | 117.59 | - | 126.9 | 124.4 | - | 115.8 | 117.94 | - | 134 | 126.19 | - |
CRPHS | 10.4 | 9.6 | - | 9.9 | 9.5 | - | 5.7 | 9.72 | - | 510 | 8.5 | - |
FIBRINOG | 494.9 | 499.1 | - | 481.0 | 506.2 | - | 456.8 | 498.58 | - | 510.8 | 489.84 | - |
SPD | 129.64 | 110.94 | - | 124.9 | 119.1 | - | 79.73 | 116.3 | * | 138.76 | 109.7 | - |
mMRC | 3 | 2.09 | ** | 1.0 | 2.4 | *** | 1.21 | 2.04 | * | 1.1 | 2.04 | * |
SGRQ | 43.29 | 55.55 | ** | 35.9 | 56.0 | *** | 41.8 | 52.87 | * | 36 | 57.73 | *** |
FFMI | 19.53 | 16.13 | *** | 18.5 | 17.1 | * | 18.48 | 17.8 | - | 18.83 | 17.15 | * |
% Fat (Tissue) | 34.92 | 29.08 | ** | 31.0 | 31.7 | - | 35.96 | 31.94 | - | 32.69 | 31.25 | - |
- | - | - | - | |||||||||
Neutrophils, % Neut_Blq | 61.38 | 64.87 | - | 60.7 | 67.0 | ** | 61.34 | 66.69 | * | 62.08 | 65.55 | - |
Eosinophils, % Eos blq | 3 | 3.1 | - | 3.5 | 3.1 | - | 2.48 | 2.92 | - | 3.26 | 3.3 | - |
Lymphocytes, % lymhblq | 28.63 | 24.84 | - | 28.6 | 23.2 | * | 29.19 | 23.55 | * | 27.77 | 23.688 | - |