Complex-based analysis of dysregulated cellular processes in cancer

BMC Systems Biology

Table 3 Changes in co-expression of complexes in pancreatic (normal-PDAC) and breast (BRCA1-BRCA2) conditions.

Complex type	Subset	Pancreatic			Breast
		Size of subset	Δ C		Size of subset	Δ C
			Max	Avg		Max	Avg
Our	$M^{'}$	159	0.969	0.336	225	0.761	0.281
	$M^{″}$	96	0.421	0.192	52	0.543	0.197
CORUM	$M^{'}$	138	0.602	0.219	386	0.642	0.178
	$M^{″}$	51	0.512	0.209	55	0.347	0.212

(The co-expression values are Fisher-transformed).
• ΔC represents the (absolute) change in co-expression of complexes between conditions, that is, increase or decrease in co-expression of complexes from normal to PDAC or BRCA1 to BRCA2 tumours.
• $M^{'}$ - complexes with co-expression for normal > PDAC tumour or BRCA1 > BRCA2 tumour. $M^{″}$ - complexes with co-expression for PDAC tumour > normal or BRCA2 > BRCA1 tumour.

ISSN: 1752-0509