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Figure 1 | BMC Systems Biology

Figure 1

From: Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection

Figure 1

Flowchart of host-pathogen interspecies interaction network construction. The Gene Ontology database was used to select C. albicans and zebrafish protein pools. Protein-protein interaction (PPI) data from the BioGRID database, ortholog information from InParanoid, and simultaneously quantified time-course microarray data for both C. albicans and zebrafish during C. albicans-zebrafish interactions were used for interspecies protein interaction network construction. Note that to construct our interspecies networks, we substituted all gene expression profiles for protein activity levels since large-scale proteomic data is still not widely available.

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BMC Systems Biology

ISSN: 1752-0509

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