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Figure 16 | BMC Systems Biology

Figure 16

From: Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection

Figure 16

The sub-network for the iron host-pathogen interaction network in the invasion stage. There were 271 interspecies interactions between C. albicans and zebrafish in the iron host-pathogen interspecies interaction network in the invasion stage. There were nine iron-related virulence proteins identified as significant in C. albicans (pink triangles) and 11 iron-related immune proteins in zebrafish (pink circles). The main functional modules for C. albicans in the invasion stage were identified to be hyphal formation (cyr1, tpk1), metal ion transport (ccc2), filamentous growth (efg1, tup1), and cellular iron ion homeostasis (ftr1, hmx1), while the main functional modules for zebrafish were identified to be the immune response (hamp1, jmjd6), metal ion transport (glrx5), and hematopoiesis-related processes (slc25a37, slc40a1, alas2, hpx, ndfip1).

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BMC Systems Biology

ISSN: 1752-0509

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