Figure 11

Scatter plots of subpopulations and P _sy variation. Colored scatter plots of subpopulations at time t = 200 versus P _sy variation remark that CSC symmetric proliferation is responsible of the two possible tumor scenarios. Specifically: black points are mainly associated with the unsustainable tumor growth, while green and red points correspond to tumorigenesis. Moreover, when P _sy takes values in (0.25, 0.5], i.e. blue points, the switching is less clear, suggesting that other parameters might influence the system behavior in these cases.