Figure 4

PRCC analysis of cell cycle model. PRCCs of input/output data revealed serum as the key parameter. Results relative to CycD and E2F during the whole time interval are reported in panels A and B, respectively. Yellow areas represent the zones of non-significant PRCC values, while blue lines correspond to serum PRCC values. The strong positive monotonic relationship between serum and model outputs is remarked, being blue lines close to one in the whole interval and isolated from the other PRCC