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Table 5 Estimated parameters for the three-module network considered as a black-box function, for different noise entities and constant CV noise model, when the function is simulated by using the three-module network of Figure 1H.

From: Modelling the effects of cell-to-cell variability on the output of interconnected gene networks in bacterial populations

Parameter:

α OUT

[RPU]

δ OUT

[RPU]

k OUT

[RPU]

η OUT

[-]

constant CV

0.22

0.22

0.22

0.20

0.20

0.20

0.19

0.19

0.19

(6.5%)

0.28

0.28

0.28

0.30

0.30

0.30

0.31

0.31

0.31

16.90

20.78

24.42

18.90

23.10

25.91

19.32

23.71

27.97

(16.2%)

1.73

1.41

1.26

1.73

1.41

1.22

1.66

1.38

1.24

(14.3%)

  1. Parameters are obtained by fitting population-averaged values of OUTPUT2 as a function of OUTPUT1 for different noise models and entity, applied to OUTPUT1. The 9 values reported in each cell correspond to a noise (which affects OUTPUT1 and OUTPUT2, respectively) of CV = 0.15-0.15, 0.15-0.55, 0.15-0.75, 0.55-0.15, 0.55-0.55, 0.55-0.75, 0.75-0.15, 0.75-0.55, 0.75-0.75. The CV among the estimated parameters is reported in brackets.