Figure 1

Predicted protein-protein association networks related to pathogenesis in P. falciparum. Yellow nodes represent the predicted functional othologs of E. coli pathogenesis proteins. Node size is proportional to the degree of the connectivity of the node. Nodes are colored according to their functional classification in the eggNOG database [80]. The COG categories are [81] (J) Translation, ribosomal structure and biogenesis, (A) RNA processing and modification, (K) Transcription, (L) Replication, recombination and repair, (B) Chromatin structure and dynamics, (D) Cell cycle control, cell division, chromosome partitioning, (Y) Nuclear structure, (V) Defense mechanisms, (T) Signal transduction mechanisms, (M) Cell wall/membrane/envelope biogenesis, (N) Cell motility, (Z) Cytoskeleton, (W) Extracellular structures, (U) Intracellular trafficking, secretion, and vesicular transport, (O) Posttranslational modification, protein turnover, chaperones, (C) Energy production and conversion, (G) Carbohydrate transport and metabolism, (E) Amino acid transport and metabolism, (F) Nucleotide transport and metabolism, (H) Coenzyme transport and metabolism, (I) Lipid transport and metabolism, (P) Inorganic ion transport and metabolism, (Q) Secondary metabolites biosynthesis, transport and catabolism, (R) General function prediction only, and (S) Function unknown. Only the interactions among the nodes having confidence scores (S values from STRING [82, 83]) greater than 0.7 were considered in this paper and are shown in the figure. The subnetworks labeled sub1 and sub2 appear in Figures 2 and 3 respectively.