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Table 1 Novel Plasmodium falciparum proteins that were predicted to be functional orthologs of pathogenesis-related proteins in E.coli

From: Predicting and exploring network components involved in pathogenesis in the malaria parasite via novel subnetwork alignments

PlasmoDB Accession Number

Annotation

Degree of Connectivity

PF3D7_1365900

60S ribosomal protein L40/UBI, putative

180

PF3D7_1241800

DEAD/DEAH box ATP-dependent RNA helicase, putative

98

PF3D7_0306800

T-complex protein beta subunit, putative

43

PF3D7_0823300

histone acetyltransferase GCN5 (GCN5)

20

PF3D7_1318700

conserved Plasmodium protein, unknown function

19

PF3D7_1212800

iron-sulfur subunit of succinate dehydrogenase

18

PF3D7_0208600

ribosome-recycling factor, putative (RRF)

16

PF3D7_1416900

prefoldin subunit 2, putative

15

PF3D7_0731100

Plasmodium exported protein (PHISTc), unknown function (GEXP11)

14

PF3D7_1013500

phosphoinositide-specific phospholipase C (PI-PLC)

11

PF3D7_0810600

RNA helicase, putative

9

PF3D7_1337200

1-deoxy-D-xylulose 5-phosphate synthase

7

PF3D7_1148800

Plasmodium exported protein (hyp11), unknown function

6

PF3D7_1008000

inositol polyphosphate kinase, putative (IPK1)

6

PF3D7_0919000

nucleosome assembly protein (NAPS)

6

PF3D7_1418000

ubiquitin fusion degradation protein UFD1, putative (UFD1)

5

PF3D7_0300100

erythrocyte membrane protein 1, PfEMP1 (VAR)

5

PF3D7_1342400

casein kinase II beta chain (CK2beta2)

1

PF3D7_1318700

conserved Plasmodium protein, unknown function

0

PF3D7_1364200

conserved Plasmodium protein, unknown function

0

PF3D7_1229300

conserved Plasmodium protein, unknown function

0

PF3D7_1451200

conserved Plasmodium protein, unknown function

0

PF3D7_0310900

conserved Plasmodium protein, unknown function

0

PF3D7_1008100

conserved Plasmodium protein, unknown function

0