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Table 6 Pathway analysis and gene set enrichment analysis of 9 proteins at 5 h post-stroke on (1) biological processes, (2) cellular components and (3) molecular functions by NOA.

From: Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data

GO: term

pvalue

Corrected pvalue

R

T

G

O

Term name

(1) Biological Processes

GO:0019941

7.3E-4

0.0316

6357

2

173

2

modification-dependent protein catabolic process

GO:0006511

7.3E-4

0.0316

6357

2

173

2

ubiquitin-dependent protein catabolic process

GO:0051603

8.3E-4

0.0358

6357

2

184

2

proteolysis involved in cellular protein catabolic process

GO:0043632

8.9E-4

0.0386

6357

2

191

2

modification-dependent macromolecule catabolic process

GO:0006508

0.0022

0.0948

6357

2

299

2

proteolysis

GO:0044265

0.0039

0.1698

6357

2

400

2

cellular macromolecule catabolic process

GO:0009057

0.0044

0.1899

6357

2

423

2

macromolecule catabolic process

GO:0006301

0.0059

0.2566

6357

2

19

1

postreplication repair

GO:0042787

0.0065

0.2836

6357

2

21

1

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO:0044248

0.0106

0.4600

6357

2

658

2

cellular catabolic process

(2) Cellular Components

GO:0031251

6.2E-4

0.0106

6357

2

2

1

PAN complex

GO:0031463

0.0015

0.0267

6357

2

5

1

Cul3-RING ubiquitin ligase complex

GO:0031461

0.0084

0.1441

6357

2

27

1

cullin-RING ubiquitin ligase complex

GO:0000151

0.0197

0.3353

6357

2

63

1

ubiquitin ligase complex

GO:0043234

0.0463

0.7879

6357

2

1369

2

protein complex

(3) Molecular Functions

GO:0004535

0.0012

0.0314

6357

2

4

1

poly(A)-specific ribonuclease activity

GO:0031625

0.0040

0.1021

6357

2

13

1

ubiquitin protein ligase binding

GO:0000175

0.0053

0.1335

6357

2

17

1

3'-5'-exoribonuclease activity

GO:0004221

0.0059

0.1492

6357

2

19

1

ubiquitin thiolesterase activity

GO:0016896

0.0065

0.1649

6357

2

21

1

exoribonuclease activity, producing 5'-phosphomonoesters

GO:0004532

0.0065

0.1649

6357

2

21

1

exoribonuclease activity

GO:0016790

0.0084

0.2119

6357

2

27

1

thiolester hydrolase activity

GO:0008408

0.0084

0.2119

6357

2

27

1

3'-5' exonuclease activity

GO:0016796

0.0097

0.2432

6357

2

31

1

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

GO:0019899

0.0112

0.2823

6357

2

36

1

enzyme binding

  1. R: number of genes in the reference set. T: number of genes in the test set. G: number of genes annotated by a given term in the reference set. O: number of genes annotated by a given term in the test set.
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BMC Systems Biology

ISSN: 1752-0509

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