Differential dependency network in budding yeast reflects the cell cycle response to oxidative stress. Red edges are connections in control and green edges are connections under stress, mutually and exclusively. Yap1, Rho1 and Msn4, the three known responders to stress response, are at the center of the inferred networks in response to oxidative stress. They are activated under oxidative stress and many connections surrounding them are activated (green edges). Acting as an antioxidant in response to oxidative stress, Ctt1 coordinate with Yap1 to protect cells from oxidative stress.